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xCell2

A Tool for Generic Cell Type Enrichment Analysis

Bioconductor version: 3.23 · Package version: 1.4.0

xCell2 provides methods for cell type enrichment analysis using cell type signatures. It includes three main functions - 1. xCell2Train for training custom references objects from bulk or single-cell RNA-seq datasets. 2. xCell2Analysis for conducting the cell type enrichment analysis using the custom reference. 3. xCell2GetLineage for identifying dependencies between different cell types using ontology.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("xCell2")

Details

MaintainerAlmog Angel <almog.angel@campus.technion.ac.il>
AuthorAlmog Angel [aut, cre] (ORCID: <https://orcid.org/0009-0001-3297-6935>), Dvir Aran [aut] (ORCID: <https://orcid.org/0000-0001-6334-5039>)
LicenseGPL (>= 3)
URLhttps://github.com/AlmogAngel/xCell2
Bug Reportshttps://github.com/AlmogAngel/xCell2/issues
Downloads rank284
Source branchRELEASE_3_23
biocViewsDifferentialExpression, GeneExpression, GeneSetEnrichment, ImmunoOncology, Microarray, RNASeq, SingleCell, Software, Transcriptomics

Documentation

Download

Dependencies

Depends: R (>= 4.0.0)

Imports: SummarizedExperiment, SingleCellExperiment, Rfast, singscore, AnnotationHub, ontologyIndex, tibble, dplyr, BiocParallel, Matrix, minpack.lm, pracma, methods, readr, magrittr, progress, quadprog

Suggests: testthat, knitr, rmarkdown, ggplot2, randomForest, tidyr, EnhancedVolcano, BiocStyle

Reverse dependencies

Suggests Me (1): VISTA