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sSNAPPY

Single Sample directioNAl Pathway Perturbation analYsis

Bioconductor version: 3.23 · Package version: 1.16.0

A single sample pathway perturbation testing method for RNA-seq data. The method propagates changes in gene expression down gene-set topologies to compute single-sample directional pathway perturbation scores that reflect potential direction of change. Perturbation scores can be used to test significance of pathway perturbation at both individual-sample and treatment levels.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("sSNAPPY")

Details

MaintainerWenjun Liu <wenjun.liu@adelaide.edu.au>
AuthorWenjun Liu [aut, cre] (ORCID: <https://orcid.org/0000-0002-8185-3069>), Stephen Pederson [aut] (ORCID: <https://orcid.org/0000-0001-8197-3303>)
LicenseGPL-3
URLhttps://wenjun-liu.github.io/sSNAPPY/
Bug Reportshttps://github.com/Wenjun-Liu/sSNAPPY/issues
System RequirementsC++11
Downloads rank263
Source branchRELEASE_3_23
biocViewsGeneExpression, GeneSetEnrichment, GeneSignaling, Software

Documentation

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Dependencies

Depends: R (>= 4.3.0), ggplot2

Imports: dplyr (>= 1.1), magrittr, rlang, stats, graphite, tibble, ggraph, igraph, reshape2, org.Hs.eg.db, SummarizedExperiment, edgeR, methods, ggforce, pheatmap, utils, stringr, gtools, tidyr

Suggests: BiocManager, BiocStyle, colorspace, cowplot, DT, htmltools, knitr, pander, patchwork, rmarkdown, spelling, testthat (>= 3.0.0), tidyverse