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quantiseqr

Quantification of the Tumor Immune contexture from RNA-seq data

Bioconductor version: 3.23 · Package version: 1.20.0

This package provides a streamlined workflow for the quanTIseq method, developed to perform the quantification of the Tumor Immune contexture from RNA-seq data. The quantification is performed against the TIL10 signature (dissecting the contributions of ten immune cell types), carefully crafted from a collection of human RNA-seq samples. The TIL10 signature has been extensively validated using simulated, flow cytometry, and immunohistochemistry data.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("quantiseqr")

Details

MaintainerFederico Marini <marinif@uni-mainz.de>
AuthorFederico Marini [aut, cre] (ORCID: <https://orcid.org/0000-0003-3252-7758>), Francesca Finotello [aut] (ORCID: <https://orcid.org/0000-0003-0712-4658>)
LicenseGPL-3
Downloads rank1183
Source branchRELEASE_3_23
biocViewsAnnotation, Classification, ExperimentHubSoftware, FeatureExtraction, FlowCytometry, GeneExpression, ImmunoOncology, Microarray, Sequencing, Software, StatisticalMethod, Transcription, Transcriptomics, Visualization

Documentation

Download

Dependencies

Depends: R (>= 4.1.0)

Imports: Biobase, limSolve, MASS, methods, preprocessCore, stats, SummarizedExperiment, ggplot2, tidyr, rlang, utils

Suggests: AnnotationDbi, BiocStyle, dplyr, ExperimentHub, GEOquery, knitr, macrophage, org.Hs.eg.db, reshape2, rmarkdown, testthat, tibble

Reverse dependencies

Imports Me (1): easier