psichomics
Graphical Interface for Alternative Splicing Quantification, Analysis and Visualisation
Bioconductor version: 3.23 · Package version: 1.38.1
Interactive R package with an intuitive Shiny-based graphical interface for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), Sequence Read Archive (SRA) and user-provided data. The tool interactively performs survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.
Installation
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("psichomics") Details
| Maintainer | Nuno Saraiva-Agostinho <nunodanielagostinho@gmail.com> |
| Author | Nuno Saraiva-Agostinho [aut, cre] (ORCID: <https://orcid.org/0000-0002-5549-105X>), Nuno Luís Barbosa-Morais [aut, led, ths] (ORCID: <https://orcid.org/0000-0002-1215-0538>), André Falcão [ths], Lina Gallego Paez [ctb], Marie Bordone [ctb], Teresa Maia [ctb], Mariana Ferreira [ctb], Ana Carolina Leote [ctb], Bernardo de Almeida [ctb] |
| License | MIT + file LICENSE |
| URL | https://nuno-agostinho.github.io/psichomics/, https://github.com/nuno-agostinho/psichomics/ |
| Bug Reports | https://github.com/nuno-agostinho/psichomics/issues |
| Downloads rank | 389 |
| Source branch | RELEASE_3_23 |
| biocViews | AlternativeSplicing, BiomedicalInformatics, DifferentialExpression, DifferentialSplicing, GUI, GeneExpression, ImmunoOncology, MultipleComparison, PrincipalComponent, RNASeq, Sequencing, Software, Survival, Transcription, Transcriptomics, Visualization |
Documentation
- Case study: command-line interface (CLI) tutorial
- Case study: visual interface tutorial
- Loading user-provided data
- Preparing an Alternative Splicing Annotation for psichomics
Download
Dependencies
Depends: R (>= 4.0), shiny (>= 1.7.0), shinyBS
Imports: AnnotationDbi, AnnotationHub, BiocFileCache, cluster, colourpicker, data.table, digest, dplyr, DT (>= 0.2), edgeR, fastICA, fastmatch, ggplot2, ggrepel, graphics, grDevices, highcharter (>= 0.5.0), htmltools, httr, jsonlite, limma, pairsD3, plyr, purrr, Rcpp (>= 0.12.14), recount, Rfast, R.utils, reshape2, shinyjs, stringr, stats, SummarizedExperiment, survival, tools, utils, XML, xtable, methods
LinkingTo: Rcpp
Suggests: testthat, knitr, parallel, devtools, rmarkdown, gplots, covr, car, rstudioapi, spelling