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psichomics

Graphical Interface for Alternative Splicing Quantification, Analysis and Visualisation

Bioconductor version: 3.23 · Package version: 1.38.1

Interactive R package with an intuitive Shiny-based graphical interface for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), Sequence Read Archive (SRA) and user-provided data. The tool interactively performs survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("psichomics")

Details

MaintainerNuno Saraiva-Agostinho <nunodanielagostinho@gmail.com>
AuthorNuno Saraiva-Agostinho [aut, cre] (ORCID: <https://orcid.org/0000-0002-5549-105X>), Nuno Luís Barbosa-Morais [aut, led, ths] (ORCID: <https://orcid.org/0000-0002-1215-0538>), André Falcão [ths], Lina Gallego Paez [ctb], Marie Bordone [ctb], Teresa Maia [ctb], Mariana Ferreira [ctb], Ana Carolina Leote [ctb], Bernardo de Almeida [ctb]
LicenseMIT + file LICENSE
URLhttps://nuno-agostinho.github.io/psichomics/, https://github.com/nuno-agostinho/psichomics/
Bug Reportshttps://github.com/nuno-agostinho/psichomics/issues
Downloads rank389
Source branchRELEASE_3_23
biocViewsAlternativeSplicing, BiomedicalInformatics, DifferentialExpression, DifferentialSplicing, GUI, GeneExpression, ImmunoOncology, MultipleComparison, PrincipalComponent, RNASeq, Sequencing, Software, Survival, Transcription, Transcriptomics, Visualization

Documentation

Download

Dependencies

Depends: R (>= 4.0), shiny (>= 1.7.0), shinyBS

Imports: AnnotationDbi, AnnotationHub, BiocFileCache, cluster, colourpicker, data.table, digest, dplyr, DT (>= 0.2), edgeR, fastICA, fastmatch, ggplot2, ggrepel, graphics, grDevices, highcharter (>= 0.5.0), htmltools, httr, jsonlite, limma, pairsD3, plyr, purrr, Rcpp (>= 0.12.14), recount, Rfast, R.utils, reshape2, shinyjs, stringr, stats, SummarizedExperiment, survival, tools, utils, XML, xtable, methods

LinkingTo: Rcpp

Suggests: testthat, knitr, parallel, devtools, rmarkdown, gplots, covr, car, rstudioapi, spelling