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nempi

Inferring unobserved perturbations from gene expression data

Bioconductor version: 3.23 · Package version: 1.20.0

Takes as input an incomplete perturbation profile and differential gene expression in log odds and infers unobserved perturbations and augments observed ones. The inference is done by iteratively inferring a network from the perturbations and inferring perturbations from the network. The network inference is done by Nested Effects Models.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("nempi")

Details

MaintainerMartin Pirkl <martinpirkl@yahoo.de>
AuthorMartin Pirkl [aut, cre]
LicenseGPL-3
URLhttps://github.com/cbg-ethz/nempi/
Bug Reportshttps://github.com/cbg-ethz/nempi/issues
Downloads rank246
Source branchRELEASE_3_23
biocViewsATACSeq, CRISPR, Classification, DNASeq, DifferentialExpression, DifferentialMethylation, GeneExpression, GeneSignaling, Network, NetworkInference, NeuralNetwork, Pathways, PooledScreens, RNASeq, SingleCell, Software, SystemsBiology

Documentation

Download

Dependencies

Depends: R (>= 4.1), mnem

Imports: e1071, nnet, randomForest, naturalsort, graphics, stats, utils, matrixStats, epiNEM

Suggests: knitr, BiocGenerics, rmarkdown, RUnit, BiocStyle