methylKit
DNA methylation analysis from high-throughput bisulfite sequencing results
Bioconductor version: 3.23 · Package version: 1.38.0
methylKit is an R package for DNA methylation analysis and annotation from high-throughput bisulfite sequencing. The package is designed to deal with sequencing data from RRBS and its variants, but also target-capture methods and whole genome bisulfite sequencing. It also has functions to analyze base-pair resolution 5hmC data from experimental protocols such as oxBS-Seq and TAB-Seq. Methylation calling can be performed directly from Bismark aligned BAM files.
Installation
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("methylKit") Details
| Maintainer | Altuna Akalin <aakalin@gmail.com>, Alexander Blume <alex.gos90@gmail.com> |
| Author | Altuna Akalin [aut, cre], Matthias Kormaksson [aut], Sheng Li [aut], Arsene Wabo [ctb], Adrian Bierling [aut], Alexander Blume [aut], Katarzyna Wreczycka [ctb] |
| License | Artistic-2.0 |
| URL | https://github.com/al2na/methylKit |
| Bug Reports | https://github.com/al2na/methylKit/issues |
| System Requirements | GNU make |
| Downloads rank | 1246 |
| Source branch | RELEASE_3_23 |
| biocViews | DNAMethylation, MethylSeq, Sequencing, Software |
Documentation
Download
Dependencies
Depends: R (>= 3.5.0), GenomicRanges (>= 1.18.1), methods
Imports: IRanges, data.table (>= 1.9.6), parallel, S4Vectors (>= 0.13.13), Seqinfo, KernSmooth, qvalue, emdbook, Rsamtools, gtools, fastseg, rtracklayer, mclust, mgcv, Rcpp, R.utils, limma, grDevices, graphics, stats, utils
LinkingTo: Rcpp, Rhtslib (>= 1.13.1)
Suggests: testthat (>= 2.1.0), knitr, rmarkdown, genomation, BiocManager
Reverse dependencies
Imports Me (3): deconvR, methInheritSim, methylInheritance