methyLImp2
Missing value estimation of DNA methylation data
Bioconductor version: 3.23 · Package version: 1.8.0
This package allows to estimate missing values in DNA methylation data. methyLImp method is based on linear regression since methylation levels show a high degree of inter-sample correlation. Implementation is parallelised over chromosomes since probes on different chromosomes are usually independent. Mini-batch approach to reduce the runtime in case of large number of samples is available.
Installation
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("methyLImp2") Details
| Maintainer | Anna Plaksienko <anna@plaxienko.com> |
| Author | Pietro Di Lena [aut] (ORCID: <https://orcid.org/0000-0002-1838-8918>), Anna Plaksienko [aut, cre] (ORCID: <https://orcid.org/0000-0001-9607-057X>), Claudia Angelini [aut] (ORCID: <https://orcid.org/0000-0001-8350-8464>), Christine Nardini [aut] (ORCID: <https://orcid.org/0000-0001-7601-321X>) |
| License | GPL-3 |
| URL | https://github.com/annaplaksienko/methyLImp2 |
| Bug Reports | https://github.com/annaplaksienko/methyLImp2/issues |
| Downloads rank | 185 |
| Source branch | RELEASE_3_23 |
| biocViews | DNAMethylation, MethylationArray, Microarray, Regression, Software |
Documentation
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Dependencies
Depends: R (>= 4.3.0), ChAMPdata
Imports: BiocParallel, parallel, stats, methods, corpcor, SummarizedExperiment, utils
Suggests: BiocStyle, knitr, rmarkdown, spelling, testthat (>= 3.0.0)