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gscreend

Analysis of pooled genetic screens

Bioconductor version: 3.23 · Package version: 1.26.0

Package for the analysis of pooled genetic screens (e.g. CRISPR-KO). The analysis of such screens is based on the comparison of gRNA abundances before and after a cell proliferation phase. The gscreend packages takes gRNA counts as input and allows detection of genes whose knockout decreases or increases cell proliferation.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("gscreend")

Details

MaintainerKatharina Imkeller <k.imkeller@dkfz.de>
AuthorKatharina Imkeller [cre, aut], Wolfgang Huber [aut]
LicenseGPL-3
URLhttps://github.com/imkeller/gscreend
Bug Reportshttps://github.com/imkeller/gscreend/issues
Downloads rank265
Source branchRELEASE_3_23
biocViewsCRISPR, PooledScreens, Software, StatisticalMethod

Documentation

Download

Dependencies

Depends: R (>= 3.6)

Imports: SummarizedExperiment, nloptr, fGarch, methods, BiocParallel, graphics

Suggests: knitr, testthat, rmarkdown, BiocStyle