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genomicInstability

Genomic Instability estimation for scRNA-Seq

Bioconductor version: 3.23 · Package version: 1.18.0

This package contain functions to run genomic instability analysis (GIA) from scRNA-Seq data. GIA estimates the association between gene expression and genomic location of the coding genes. It uses the aREA algorithm to quantify the enrichment of sets of contiguous genes (loci-blocks) on the gene expression profiles and estimates the Genomic Instability Score (GIS) for each analyzed cell.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("genomicInstability")

Details

MaintainerMariano Alvarez <reef103@gmail.com>
AuthorMariano Alvarez [aut, cre], Pasquale Laise [aut], DarwinHealth [cph]
Licensefile LICENSE
URLhttps://github.com/DarwinHealth/genomicInstability
Bug Reportshttps://github.com/DarwinHealth/genomicInstability
Downloads rank229
Source branchRELEASE_3_23
biocViewsGeneExpression, SingleCell, Software, SystemsBiology

Documentation

Download

Dependencies

Depends: R (>= 4.1.0), checkmate

Imports: mixtools, SummarizedExperiment

Suggests: SingleCellExperiment, ExperimentHub, pROC