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epialleleR

Fast, Accurate, Epiallele-Aware Methylation Caller and Reporter

Bioconductor version: 3.23 · Package version: 1.20.0

Epialleles are specific DNA methylation patterns that are mitotically and/or meiotically inherited. This package calls and reports cytosine methylation as well as frequencies of hypermethylated epialleles at the level of genomic regions or individual cytosines in next-generation sequencing data using binary alignment map (BAM) files as an input. Among other things, this package can also extract and visualise methylation patterns and assess allele specificity of methylation.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("epialleleR")

Details

MaintainerOleksii Nikolaienko <oleksii.nikolaienko@gmail.com>
AuthorOleksii Nikolaienko [aut, cre] (ORCID: <https://orcid.org/0000-0002-5910-4934>)
LicenseArtistic-2.0
URLhttps://github.com/BBCG/epialleleR
Bug Reportshttps://github.com/BBCG/epialleleR/issues
System RequirementsC++17, GNU make
Downloads rank292
Source branchRELEASE_3_23
biocViewsDNAMethylation, Epigenetics, LongRead, MethylSeq, Software

Documentation

Download

Dependencies

Depends: R (>= 4.1)

Imports: stats, methods, utils, data.table, BiocGenerics, GenomicRanges, Rcpp

LinkingTo: Rcpp, BH, Rhtslib

Suggests: GenomeInfoDb, SummarizedExperiment, VariantAnnotation, RUnit, knitr, rmarkdown, ggplot2