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enhancerHomologSearch

Identification of putative mammalian orthologs to given enhancer

Bioconductor version: 3.23 · Package version: 1.18.0

Get ENCODE data of enhancer region via H3K4me1 peaks and search homolog regions for given sequences. The candidates of enhancer homolog regions can be filtered by distance to target TSS. The top candidates from human and mouse will be aligned to each other and then exported as multiple alignments with given enhancer.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("enhancerHomologSearch")

Details

MaintainerJianhong Ou <jou@morgridge.org>
AuthorJianhong Ou [aut, cre] (ORCID: <https://orcid.org/0000-0002-8652-2488>), Valentina Cigliola [dtc], Kenneth Poss [fnd]
LicenseGPL (>= 2)
URLhttps://jianhong.github.io/enhancerHomologSearch
Bug Reportshttps://github.com/jianhong/enhancerHomologSearch/issues
Downloads rank261
Source branchRELEASE_3_23
biocViewsAlignment, GeneRegulation, Sequencing, Software

Documentation

Download

Dependencies

Depends: R (>= 4.1.0), methods

Imports: BiocGenerics, Biostrings, BSgenome, BiocParallel, BiocFileCache, Seqinfo, GenomicRanges, httr, IRanges, jsonlite, motifmatchr, Matrix, pwalign, rtracklayer, Rcpp, S4Vectors, stats, utils

LinkingTo: Rcpp

Suggests: GenomeInfoDb, knitr, rmarkdown, BSgenome.Drerio.UCSC.danRer10, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm10, TxDb.Hsapiens.UCSC.hg38.knownGene, org.Hs.eg.db, TxDb.Mmusculus.UCSC.mm10.knownGene, org.Mm.eg.db, MotifDb, testthat, TFBSTools