enhancerHomologSearch
Identification of putative mammalian orthologs to given enhancer
Bioconductor version: 3.23 · Package version: 1.18.0
Get ENCODE data of enhancer region via H3K4me1 peaks and search homolog regions for given sequences. The candidates of enhancer homolog regions can be filtered by distance to target TSS. The top candidates from human and mouse will be aligned to each other and then exported as multiple alignments with given enhancer.
Installation
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("enhancerHomologSearch") Details
| Maintainer | Jianhong Ou <jou@morgridge.org> |
| Author | Jianhong Ou [aut, cre] (ORCID: <https://orcid.org/0000-0002-8652-2488>), Valentina Cigliola [dtc], Kenneth Poss [fnd] |
| License | GPL (>= 2) |
| URL | https://jianhong.github.io/enhancerHomologSearch |
| Bug Reports | https://github.com/jianhong/enhancerHomologSearch/issues |
| Downloads rank | 261 |
| Source branch | RELEASE_3_23 |
| biocViews | Alignment, GeneRegulation, Sequencing, Software |
Documentation
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Dependencies
Depends: R (>= 4.1.0), methods
Imports: BiocGenerics, Biostrings, BSgenome, BiocParallel, BiocFileCache, Seqinfo, GenomicRanges, httr, IRanges, jsonlite, motifmatchr, Matrix, pwalign, rtracklayer, Rcpp, S4Vectors, stats, utils
LinkingTo: Rcpp
Suggests: GenomeInfoDb, knitr, rmarkdown, BSgenome.Drerio.UCSC.danRer10, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm10, TxDb.Hsapiens.UCSC.hg38.knownGene, org.Hs.eg.db, TxDb.Mmusculus.UCSC.mm10.knownGene, org.Mm.eg.db, MotifDb, testthat, TFBSTools