derfinder
Annotation-agnostic differential expression analysis of RNA-seq data at base-pair resolution via the DER Finder approach
Bioconductor version: 3.23 · Package version: 1.46.0
This package provides functions for annotation-agnostic differential expression analysis of RNA-seq data. Two implementations of the DER Finder approach are included in this package: (1) single base-level F-statistics and (2) DER identification at the expressed regions-level. The DER Finder approach can also be used to identify differentially bounded ChIP-seq peaks.
Installation
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("derfinder") Details
| Maintainer | Leonardo Collado-Torres <lcolladotor@gmail.com> |
| Author | Leonardo Collado-Torres [aut, cre] (ORCID: <https://orcid.org/0000-0003-2140-308X>), Alyssa C. Frazee [ctb], Andrew E. Jaffe [aut] (ORCID: <https://orcid.org/0000-0001-6886-1454>), Jeffrey T. Leek [aut, ths] (ORCID: <https://orcid.org/0000-0002-2873-2671>) |
| License | Artistic-2.0 |
| URL | https://github.com/lcolladotor/derfinder |
| Bug Reports | https://support.bioconductor.org/t/derfinder/ |
| Downloads rank | 946 |
| Source branch | RELEASE_3_23 |
| biocViews | ChIPSeq, Coverage, DifferentialExpression, DifferentialPeakCalling, ImmunoOncology, RNASeq, Sequencing, Software |
Documentation
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Dependencies
Depends: R (>= 3.5.0)
Imports: BiocGenerics (>= 0.25.1), AnnotationDbi (>= 1.27.9), BiocParallel (>= 1.15.15), bumphunter (>= 1.9.2), derfinderHelper (>= 1.1.0), Seqinfo (>= 0.99.2), GenomeInfoDb (>= 1.45.9), GenomicAlignments, GenomicFeatures, GenomicFiles, GenomicRanges (>= 1.61.1), Hmisc, IRanges (>= 2.3.23), methods, qvalue (>= 1.99.0), Rsamtools (>= 2.25.1), rtracklayer, S4Vectors (>= 0.23.19), stats, utils
Suggests: BiocStyle (>= 2.5.19), sessioninfo, derfinderData (>= 0.99.0), derfinderPlot, DESeq2, ggplot2, knitr (>= 1.6), limma, RefManageR, rmarkdown (>= 0.3.3), testthat (>= 2.1.0), TxDb.Hsapiens.UCSC.hg19.knownGene, covr
Reverse dependencies
Imports Me (5): derfinderPlot, GenomicState, recount, recountWorkflow, regionReport
Suggests Me (1): megadepth