decompTumor2Sig

Decomposition of individual tumors into mutational signatures by signature refitting

Bioconductor version: 3.23 · Package version: 2.28.1

Uses quadratic programming for signature refitting, i.e., to decompose the mutation catalog from an individual tumor sample into a set of given mutational signatures (either Alexandrov-model signatures or Shiraishi-model signatures), computing weights that reflect the contributions of the signatures to the mutation load of the tumor.

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("decompTumor2Sig")