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betterChromVAR

Improved ChromVAR (Chromatin Variation Across Regions)

Bioconductor version: 3.23 · Package version: 1.0.3

A much faster analytical implementation of chromVAR, with additional features, used to infer TF activity from (bulk or single-cell) ATAC-seq data and motif annotations (or binding probabilities). The package also includes the CVnorm normalization method based on the chromVAR logic.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("betterChromVAR")

Details

MaintainerPierre-Luc Germain <pierre-luc.germain@hest.ethz.ch>
AuthorPierre-Luc Germain [aut, cre] (ORCID: <https://orcid.org/0000-0003-3418-4218>)
LicenseGPL (>= 3)
URLhttps://github.com/plger/betterChromVAR
Bug Reportshttps://github.com/plger/betterChromVAR/issues
Downloads rank56
Source branchRELEASE_3_23
biocViewsATACSeq, Epigenetics, Normalization, Sequencing, Software

Documentation

Download

Dependencies

Depends: SummarizedExperiment

Imports: BiocParallel, Biostrings, GenomicRanges, IRanges, Matrix, matrixStats, methods, S4Vectors, stats

Suggests: BiocStyle, knitr, rmarkdown, sessioninfo, testthat