Bioc2026 Registration Open!

TOAST

Tools for the analysis of heterogeneous tissues

Bioconductor version: 3.23 · Package version: 1.26.0

This package is devoted to analyzing high-throughput data (e.g. gene expression microarray, DNA methylation microarray, RNA-seq) from complex tissues. Current functionalities include 1. detect cell-type specific or cross-cell type differential signals 2. tree-based differential analysis 3. improve variable selection in reference-free deconvolution 4. partial reference-free deconvolution with prior knowledge.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("TOAST")

Details

MaintainerZiyi Li <zli16@mdanderson.org>
AuthorZiyi Li and Weiwei Zhang and Luxiao Chen and Hao Wu
LicenseGPL-2
Bug Reportshttps://github.com/ziyili20/TOAST/issues
Downloads rank850
Source branchRELEASE_3_23
biocViewsDNAMethylation, DifferentialExpression, DifferentialMethylation, Epigenetics, GeneExpression, GeneTarget, MethylationArray, Microarray, Software

Documentation

Download

Dependencies

Depends: R (>= 3.6), EpiDISH, limma, nnls, quadprog

Imports: stats, methods, SummarizedExperiment, corpcor, doParallel, parallel, ggplot2, tidyr, GGally

Suggests: BiocStyle, knitr, rmarkdown, gplots, matrixStats, Matrix

Reverse dependencies

Imports Me (3): cypress, MICSQTL, RegionalST