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SpliceImpactR

An R package to identify functional impacts due to alternative RNA processing events

Bioconductor version: 3.23 · Package version: 1.0.0

Works by taking in processed data from the HIT Index and/or rMATS and identifying how differentially used alternative RNA processing events lead to changes in protein function through various means. Primarily this is done through protein similarity, functional protein domain analysis, and domain-domain interaction changes. Notably, we both identify alterantive RNA processing event 'swaps' across condition and are able to perform holistic analyses regarding the impact of different RNA processing events.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("SpliceImpactR")

Details

MaintainerZachary Wakefield <zachpw@bu.edu>
AuthorZachary Wakefield [cre, aut] (ORCID: <https://orcid.org/0000-0002-9104-0934>), Ana Fiszbein [aut]
LicenseGPL-3
Bug Reportshttps://github.com/fiszbein-lab/SpliceImpactR/issues
Downloads rank46
Source branchRELEASE_3_23
biocViewsAlignment, AlternativeSplicing, DifferentialSplicing, Software, StatisticalMethod

Documentation

Download

Dependencies

Depends: R (>= 3.5.0)

Imports: data.table, BiocFileCache, BiocParallel, Biostrings, GenomicRanges, SummarizedExperiment, biomaRt, IRanges, PFAM.db, dplyr, ggplot2, ggpubr, patchwork, pwalign, rtracklayer, scales, stats, tidyr, tools, utils, magrittr, methods, S4Vectors

Suggests: devtools, testthat (>= 3.0.0), knitr, rmarkdown, cowplot, stringr, readr, tibble, BiocStyle, clusterProfiler, AnnotationDbi, msigdbr, org.Hs.eg.db, org.Mm.eg.db