SpliceImpactR
An R package to identify functional impacts due to alternative RNA processing events
Bioconductor version: 3.23 · Package version: 1.0.0
Works by taking in processed data from the HIT Index and/or rMATS and identifying how differentially used alternative RNA processing events lead to changes in protein function through various means. Primarily this is done through protein similarity, functional protein domain analysis, and domain-domain interaction changes. Notably, we both identify alterantive RNA processing event 'swaps' across condition and are able to perform holistic analyses regarding the impact of different RNA processing events.
Installation
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("SpliceImpactR") Details
| Maintainer | Zachary Wakefield <zachpw@bu.edu> |
| Author | Zachary Wakefield [cre, aut] (ORCID: <https://orcid.org/0000-0002-9104-0934>), Ana Fiszbein [aut] |
| License | GPL-3 |
| Bug Reports | https://github.com/fiszbein-lab/SpliceImpactR/issues |
| Downloads rank | 46 |
| Source branch | RELEASE_3_23 |
| biocViews | Alignment, AlternativeSplicing, DifferentialSplicing, Software, StatisticalMethod |
Documentation
Download
Dependencies
Depends: R (>= 3.5.0)
Imports: data.table, BiocFileCache, BiocParallel, Biostrings, GenomicRanges, SummarizedExperiment, biomaRt, IRanges, PFAM.db, dplyr, ggplot2, ggpubr, patchwork, pwalign, rtracklayer, scales, stats, tidyr, tools, utils, magrittr, methods, S4Vectors
Suggests: devtools, testthat (>= 3.0.0), knitr, rmarkdown, cowplot, stringr, readr, tibble, BiocStyle, clusterProfiler, AnnotationDbi, msigdbr, org.Hs.eg.db, org.Mm.eg.db