Bioc2026 Registration Open!

RTN

RTN: Reconstruction of Transcriptional regulatory Networks and analysis of regulons

Bioconductor version: 3.23 · Package version: 2.36.0

A transcriptional regulatory network (TRN) consists of a collection of transcription factors (TFs) and the regulated target genes. TFs are regulators that recognize specific DNA sequences and guide the expression of the genome, either activating or repressing the expression the target genes. The set of genes controlled by the same TF forms a regulon. This package provides classes and methods for the reconstruction of TRNs and analysis of regulons.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("RTN")

Details

MaintainerMauro Castro <mauro.a.castro@gmail.com>
AuthorClarice Groeneveld [ctb], Gordon Robertson [ctb], Xin Wang [aut], Michael Fletcher [aut], Florian Markowetz [aut], Kerstin Meyer [aut], and Mauro Castro [aut]
LicenseArtistic-2.0
URLhttp://dx.doi.org/10.1038/ncomms3464
Downloads rank519
Source branchRELEASE_3_23
biocViewsGeneExpression, GeneRegulation, GeneSetEnrichment, GeneticVariability, GraphAndNetwork, Network, NetworkEnrichment, NetworkInference, Software, Transcription

Documentation

Download

Dependencies

Depends: R (>= 3.6.3), methods

Imports: RedeR, minet, viper, mixtools, snow, stats, limma, data.table, IRanges, igraph, S4Vectors, SummarizedExperiment, car, pwr, pheatmap, grDevices, graphics, utils

Suggests: RUnit, BiocGenerics, BiocStyle, knitr, rmarkdown

Reverse dependencies

Depends On Me (3): Fletcher2013b, RTNduals, RTNsurvival

Suggests Me (1): geneplast