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MotifPeeker

Benchmarking Epigenomic Profiling Methods Using Motif Enrichment

Bioconductor version: 3.23 · Package version: 1.4.0

MotifPeeker is used to compare and analyse datasets from epigenomic profiling methods with motif enrichment as the key benchmark. The package outputs an HTML report consisting of three sections: (1. General Metrics) Overview of peaks-related general metrics for the datasets (FRiP scores, peak widths and motif-summit distances). (2. Known Motif Enrichment Analysis) Statistics for the frequency of user-provided motifs enriched in the datasets. (3. Motif Discovery Enrichment Analysis) Statistics for the frequency of ab-initio discovered motifs enriched in the datasets and compared with known motifs.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("MotifPeeker")

Details

MaintainerHiranyamaya Dash <hdash.work@gmail.com>
AuthorHiranyamaya Dash [cre, aut] (ORCID: <https://orcid.org/0009-0005-5514-505X>), Thomas Roberts [aut] (ORCID: <https://orcid.org/0009-0006-6244-8670>), Maria Weinert [aut] (ORCID: <https://orcid.org/0000-0001-6187-1000>), Nathan Skene [aut] (ORCID: <https://orcid.org/0000-0002-6807-3180>)
LicenseGPL (>= 3)
URLhttps://github.com/neurogenomics/MotifPeeker
Bug Reportshttps://github.com/neurogenomics/MotifPeeker/issues
System RequirementsMEME Suite (v5.3.3 or above) <http://meme-suite.org/doc/download.html>
Downloads rank151
Source branchRELEASE_3_23
biocViewsAlignment, ChIPSeq, Epigenetics, FunctionalGenomics, Genetics, MotifDiscovery, MultipleComparison, QualityControl, SequenceMatching, Software

Documentation

Download

Dependencies

Depends: R (>= 4.5.0)

Imports: BiocFileCache, BiocParallel, DT, ggplot2, plotly, universalmotif, GenomicRanges, IRanges, rtracklayer, tools, htmltools, rmarkdown, viridis, SummarizedExperiment, htmlwidgets, Rsamtools, GenomicAlignments, Seqinfo, Biostrings, BSgenome, memes, S4Vectors, dplyr, purrr, tidyr, heatmaply, stats, utils

Suggests: BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm10, BSgenome.Mmusculus.UCSC.mm39, downloadthis, knitr, markdown, methods, remotes, rworkflows, testthat (>= 3.0.0), withr, emoji, curl, jsonlite