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Motif2Site

Detect binding sites from motifs and ChIP-seq experiments, and compare binding sites across conditions

Bioconductor version: 3.23 · Package version: 1.16.0

Detect binding sites using motifs IUPAC sequence or bed coordinates and ChIP-seq experiments in bed or bam format. Combine/compare binding sites across experiments, tissues, or conditions. All normalization and differential steps are done using TMM-GLM method. Signal decomposition is done by setting motifs as the centers of the mixture of normal distribution curves.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("Motif2Site")

Details

MaintainerPeyman Zarrineh <peyman.zarrineh@manchester.ac.uk>
AuthorPeyman Zarrineh [cre, aut] (ORCID: <https://orcid.org/0000-0003-4820-4101>)
LicenseGPL-2
Bug Reportshttps://github.com/fls-bioinformatics-core/Motif2Site/issues
Downloads rank243
Source branchRELEASE_3_23
biocViewsChIPSeq, DifferentialPeakCalling, Epigenetics, SequenceMatching, Sequencing, Software

Documentation

Download

Dependencies

Depends: R (>= 4.1)

Imports: S4Vectors, stats, utils, methods, grDevices, graphics, BiocGenerics, BSgenome, GenomeInfoDb, MASS, IRanges, GenomicRanges, Biostrings, GenomicAlignments, edgeR, mixtools

Suggests: BiocStyle, rmarkdown, knitr, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm10, BSgenome.Scerevisiae.UCSC.sacCer3, BSgenome.Ecoli.NCBI.20080805