HiBED

Bioconductor version: 3.23 · Package version: 1.10.0

Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation. The HiBED deconvolution estimates proportions up to 7 cell types (GABAergic neurons, glutamatergic neurons, astrocytes, microglial cells, oligodendrocytes, endothelial cells, and stromal cells) in bulk brain tissues.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("HiBED")

Details

Maintainer	Ze Zhang <ze.zhang.gr@dartmouth.edu>
Author	Ze Zhang [cre, aut] (ORCID: <https://orcid.org/0000-0001-9854-5823>), Lucas A. Salas [aut]
License	GPL-3
URL	https://github.com/SalasLab/HiBED
Bug Reports	https://github.com/SalasLab/HiBED/issues.
Downloads rank	93
Source branch	RELEASE_3_23
biocViews	ExperimentData, Genome, Homo_sapiens_Data, MethylationArrayData, MicroarrayData, PackageTypeData, Tissue

Download

Source package

Dependencies

Depends: R (>= 3.5.0)

Imports: dplyr, FlowSorted.Blood.EPIC, tibble, FlowSorted.DLPFC.450k, minfi, utils, AnnotationHub, SummarizedExperiment

Suggests: knitr, rmarkdown, testthat, IlluminaHumanMethylation450kmanifest