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GeoDiff

Count model based differential expression and normalization on GeoMx RNA data

Bioconductor version: 3.23 · Package version: 1.18.0

A series of statistical models using count generating distributions for background modelling, feature and sample QC, normalization and differential expression analysis on GeoMx RNA data. The application of these methods are demonstrated by example data analysis vignette.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("GeoDiff")

Details

MaintainerMaddy Griswold <mgriswold@nanostring.com>
AuthorMaddy Griswold [cre], Lei Yang [aut], Zhi Yang [aut]
LicenseMIT + file LICENSE
URLhttps://github.com/Nanostring-Biostats/GeoDiff
Bug Reportshttps://github.com/Nanostring-Biostats/GeoDiff
Downloads rank260
Source branchRELEASE_3_23
biocViewsDifferentialExpression, GeneExpression, Normalization, Software

Documentation

Download

Dependencies

Depends: R (>= 4.1.0), Biobase

Imports: Matrix, robust, plyr, lme4, Rcpp (>= 1.0.4.6), withr, methods, graphics, stats, testthat, GeomxTools, NanoStringNCTools

LinkingTo: Rcpp, RcppArmadillo, roptim

Suggests: knitr, rmarkdown, dplyr