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DegCre

Probabilistic association of DEGs to CREs from differential data

Bioconductor version: 3.23 · Package version: 1.8.0

DegCre generates associations between differentially expressed genes (DEGs) and cis-regulatory elements (CREs) based on non-parametric concordance between differential data. The user provides GRanges of DEG TSS and CRE regions with differential p-value and optionally log-fold changes and DegCre returns an annotated Hits object with associations and their calculated probabilities. Additionally, the package provides functionality for visualization and conversion to other formats.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("DegCre")

Details

MaintainerBrian S. Roberts <brianroberts1976@yahoo.com>
AuthorBrian S. Roberts [aut, cre] (ORCID: <https://orcid.org/0009-0001-2914-6826>)
LicenseMIT + file LICENSE
URLhttps://github.com/brianSroberts/DegCre
Bug Reportshttps://github.com/brianSroberts/DegCre/issues
Downloads rank203
Source branchRELEASE_3_23
biocViewsATACSeq, ChIPSeq, DNaseSeq, GeneExpression, GeneRegulation, RNASeq, Software

Documentation

Download

Dependencies

Depends: R (>= 4.4)

Imports: GenomicRanges, InteractionSet, plotgardener, S4Vectors, stats, graphics, grDevices, BiocGenerics, Seqinfo, IRanges, BiocParallel, qvalue, TxDb.Hsapiens.UCSC.hg38.knownGene, org.Hs.eg.db, utils

Suggests: BSgenome, BSgenome.Hsapiens.UCSC.hg38, BiocStyle, magick, knitr, rmarkdown, TxDb.Mmusculus.UCSC.mm10.knownGene, testthat (>= 3.0.0)