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ChIPseeker

ChIPseeker for ChIP peak Annotation, Comparison, and Visualization

Bioconductor version: 3.23 · Package version: 1.48.0

This package implements functions to retrieve the nearest genes around the peak, annotate genomic region of the peak, statstical methods for estimate the significance of overlap among ChIP peak data sets, and incorporate GEO database for user to compare the own dataset with those deposited in database. The comparison can be used to infer cooperative regulation and thus can be used to generate hypotheses. Several visualization functions are implemented to summarize the coverage of the peak experiment, average profile and heatmap of peaks binding to TSS regions, genomic annotation, distance to TSS, and overlap of peaks or genes.

Installation

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("ChIPseeker")

Details

MaintainerGuangchuang Yu <guangchuangyu@gmail.com>
AuthorGuangchuang Yu [aut, cre] (ORCID: <https://orcid.org/0000-0002-6485-8781>), Ming Li [ctb], Qianwen Wang [ctb], Yun Yan [ctb], Hervé Pagès [ctb], Michael Kluge [ctb], Thomas Schwarzl [ctb], Zhougeng Xu [ctb], Chun-Hui Gao [ctb] (ORCID: <https://orcid.org/0000-0002-1445-7939>)
LicenseArtistic-2.0
URLhttps://yulab-smu.top/contribution-knowledge-mining/
Bug Reportshttps://github.com/YuLab-SMU/ChIPseeker/issues
Downloads rank3046
Source branchRELEASE_3_23
biocViewsAnnotation, ChIPSeq, MultipleComparison, Software, Visualization

Documentation

Download

Dependencies

Depends: R (>= 4.1.0)

Imports: AnnotationDbi, aplot, BiocGenerics, boot, dplyr, enrichplot, IRanges, GenomeInfoDb, GenomicRanges, GenomicFeatures, ggplot2, gplots, graphics, grDevices, gtools, magrittr, methods, plotrix, parallel, RColorBrewer, rlang, rtracklayer, S4Vectors, scales, stats, tibble, TxDb.Hsapiens.UCSC.hg19.knownGene, utils, yulab.utils (>= 0.2.0)

Suggests: clusterProfiler, ggimage, ggplotify, ggupset, ggVennDiagram, knitr, org.Hs.eg.db, prettydoc, ReactomePA, rmarkdown, testthat, TxDb.Hsapiens.UCSC.hg38.knownGene

Reverse dependencies

Imports Me (5): EpiCompare, epiRomics, esATAC, profileplyr, segmenter

Suggests Me (3): cinaR, curatedAdipoChIP, GRaNIE